Effect of tumor necrosis factor-alpha on brain damage following experimental intracerebral hemorrhage in rats
- VernacularTitle:肿瘤坏死因子-?在大鼠实验性脑出血脑损伤中的作用
- Author:
Xiu CHEN
;
Zuoxiao LI
;
Qiuqiong SHE
- Publication Type:Journal Article
- Keywords:
intracerebral hemorrhage;
tumor necrosis factor-alpha;
brain damage;
brain edema
- From:
Journal of Clinical Neurology
2001;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect of tumor necrosis factor-alpha(TNF-?) on brain damage following experimental intracerebral hemorrhage(ICH) in rats.Methods We induced intracerebral hemorrhage models of rats with injecting autologous blood into the left caudate.The levels of TNF-? and water contents in perihematoma at different stages were examined by radioimmunoassay and wet-dry weight measurement,and neurobehavioral outcomes were assessed in the meanwhile.Results The levels of TNF-? at 12~96 h in ICH group were higher than those in control group(all(P
