Relationship between chemokins MCP-1,RANTES and experimental allergic neuritis
- VernacularTitle:单核细胞趋化蛋白-1和调节活化正常T细胞表达分泌因子与实验性变态反应性神经炎的关系
- Author:
Ying ZHOU
;
Bo XIAO
;
Wenbin ZHOU
- Publication Type:Journal Article
- Keywords:
experimental allergic neuritis;
MCP-1;
RANTES
- From:
Journal of Clinical Neurology
2001;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the relationship between chemokines monocyte chemoattractant protein-1(MCP-1),reduced upon activation of normal T cell expressed and secreted chemokine(RANTES) and experimental allergic neuritis(EAN).Methods EAN models were induced in Wistar rats by immunization with rabbit sciatic nerves homogenate and complete Freund's adjuvant(CFA).Expressions of MCP-1,RANTES in the sciatic nerves of experimental rats were detected by immunohistochemistry technology at different time.Results The maximum MCP-1 positive cells in the sciatic nerves were detected at 9th d.The expression of MCP-1 in EAN group was obviously higher than that in control group at 9th,15th and 21th d(all(P
