Inhibitors of differentiation and tumors
- VernacularTitle:细胞分化抑制因子与肿瘤
- Author:
Tingting FAN
;
Xiaojun LI
- Publication Type:Journal Article
- Keywords:
Inhibitors of differentiation;
Helix-loop-helix type transcription factor;
Tumor
- From:
Journal of Medical Postgraduates
2003;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Inhibitors of differentiation(Id) are negative regulators of basic helix-loop-helix(bHLH) type transcription factor.There are four related members of the Id family called Id-1,Id-2,Id-3 and(Id-4) in mammalian cells.Since the identification of Id proteins in 1990,the roles of Id in cell proliferation,differentiation,development,maturation,apoptosis and tumorigenesis have been widely investigated.This article focuses on the role of Id in tumorigenesis.
