Use of dexamethasone in combination with azasetron for postoperative nausea and vomiting after laparoscopic cholecystectomy-A randomized controlled trial
- VernacularTitle:地塞米松复合阿扎司琼对腹腔镜胆囊切除术后恶心呕吐影响的随机对照研究
- Author:
Minghui CAO
;
Zhonghua CHU
;
Lei ZHANG
- Publication Type:Journal Article
- Keywords:
Dexamethasone;
Azasetron;
Nausea and vomiting;
Laparoscopic cholecystectomy
- From:
Chinese Journal of Minimally Invasive Surgery
2005;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effectiveness of dexamethasone combined with azasetron for the prevention of postoperative nausea and vomiting(PONV) in patients after laparoscopic cholecystectomy(LC).Methods A total of 150 ASA(Ⅰ~Ⅱ) patients undergoing an elective LC were randomly divided into three groups with 50 patients in each group: Group D+A was given intravenous dexamethasone 5mg and azasetron 10mg(2ml) at the end of surgery,Group A received intravenous azasetron 10mg(2ml) at the end of surgery,and Group C received normal saline(NS) 2 ml as the control.Episodes of nausea and vomiting were recorded for 24 h following the surgery.Results The incidence of nausea was 4% in the Group D+A(2/50),which was significantly lower than in the Group A(16%,8/50) and the Group C(34%,17/50)(?~2=4.00 and 14.62;P=0.046 and 0.000).The incidence of vomiting was 2% in the Group D+A(1/50),which was significantly lower than in the Group A (14%,(7/50)) and the Group C(32%,16/50)(?~2=4.89 and 15.95;P=0.027 and 0.000).The incidences of nausea and vomiting were significantly lower in the Group A than in the Group C(?~2=4.32 and 4.57;P=0.038 and 0.033).Conclusions Use of a low dose of dexamethasone in combination with azasetron is more effective than azasetron prophylaxis alone for a successful control of PONV after LC.
