On the relationship between gallstones and cholecystokinin-A receptor and vasoactive intestinal poly-peptide
- VernacularTitle:胆囊结石与胆囊收缩素受体(CCK-A)和血管活性肠肽(VIP)的关系研究
- Author:
Yuemin CAO
;
Dianbin NING
;
Wanxing ZHANG
- Publication Type:Journal Article
- Keywords:
Cholecystokinin receptor;
Vasoactive intestinal poly-peptide;
Radioimmunoassay;
Gene expression
- From:
Chinese Journal of Minimally Invasive Surgery
2005;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To discuss the effect of abnormal biliary dynamics on the formation of cholelithiasis.Methods A total of 35 cases of gallstone(Gallstone Group),25 cases of gallbladder polypoid lesions(Polypus Group),and 30 normal cases(Control Group) were included in this study.The fasting gallbladder volume was measured with B-ultrasonography,the serum concentration of vasoactive intestinal poly-peptide(VIP) was determined with radioimmunoassay,and the expression of cholecystokinin-A(CCK-A) receptor in the gallbladder mucous membrane was detected with reverse transcriptase polymerase chain reactions(rt-PCR). Results ①The fasting gallbladder volume was significantly greater in the Gallstone Group than in the other two groups(F=3.45,P=0.039).②The gallbladder contraction rate was significantly lower in the Gallstone Group than in the other two groups(F=5.747,P=0.005).③The postprandial increases of VIP of the three groups were not of statistical significance(F=0.768,P=0.47).④Compared with the Polypus Group,the expression of CCK-A receptor in the Gallstone Group was significantly decreased(t?=4.390,P=0.022).Conclusions ① The increase of the fasting gallbladder volume in the Gallstone Group is associated with the formation of gallstones.②In the Gallstone Group,depressed gallbladder contraction results in the formation of gallstones.③The decreased expression of CCK-A receptor leads to depressed gallbladder contraction,which facilitates the formation of gallstones.④Serum VIP is not related to the formation of gallstones.
