Intracellular Ca~(2+) in detrusor cell of unstable bladder of rabbit's partial bladder outlet obstruction
- VernacularTitle:梗阻性不稳定膀胱逼尿肌细胞内Ca~(2+)的变化及意义
- Author:
Wen CHENG
;
Jianping GAO
;
Zhengyu ZHANG
- Publication Type:Journal Article
- Keywords:
Ca~(2+);
Bladder outlet obstruction,rabbit;
Unstable bladder
- From:
Journal of Medical Postgraduates
2003;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study Ca~(2 +) changes~( )in detrusor cell of the unstable bladder of rabbit~(,)s partial bladder outlet obstruction. Methods: Thirty male New Zealand White rabbits were divided into 2 groups randomly. In the experiment group the unstable bladder were confirmed by Urodynamics and the sham operated age-matched rabbits acted as the control group eight weeks after operetion. bladder smooth muscle cells were isolated by collagenase digestion. Intracellular Ca~(2+) levels in detrusor cell were observed by confocal laser scanning microscope (CLSM). Results: Intracellular Ca~(2+) concentration significantly increased in the experiment group (Ca~(2+) overload). Conclusion:It was a important pathogeny for the unstable bladder of partial bladder outlet obstruction that pathological changes of Ca~(2+) with the unstable bladder.
