Role of transforming growth factor?1 in pathogenesis of human polycystic kidney disease
- VernacularTitle:转化生长因子?1在人多囊肾病发病中的作用
- Author:
Bing TANG
;
Changlin MEI
;
Tianmei SUN
;
Ling ZHANG
;
Jianquan ZHANG
;
Ji SONG
;
Xuefei SHEN
;
Wenjing WANG
;
Yumei WU
- Publication Type:Journal Article
- Keywords:
Polycystic kidney disease, autosomal dominant;
Transforming growth factor-?1;
(TGF-?) receptors;
Connective tissue growth factor;
Renal interstitial fibrosis
- From:
Journal of Medical Postgraduates
2003;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate characteristic expression of TGF-?1 in human ADPKD and clarify its role in the development and progression of human ADPKD. Methods:Cyst fluid, urinary and plasma TGF-?1 levels were determined by ELISA in 39 ADPKD patients. The results were compared with those of normal subjects and of patients with simple renal cyst. TGF-?1, TGF-?1 receptors types Ⅰ, types Ⅱ, CTGF mRNA and proteins in the kidneys of human ADPKD were examined by in situ hybridization and immunohistochemistry. The relationship of the above fibrosing-associated indicators with the degree of interstitial fibrosis was analyzed. Results:Plasma TGF-?1 level was the highest among body fluids. In ADPKD and simple renal cyst, TGF-?1 levels were significantly higher than those in normal subjects (15.12 ?8.53)?g/L vs (5.41?1.31) ?g/L,P
