The structure of epstein-barr virus latent membrane protein 1 and its signal transduction
- VernacularTitle:爱泼斯坦-巴尔病毒潜伏膜蛋白1的结构和信号转导
- Author:
Yingchun HE
;
Daofa TIAN
- Publication Type:Journal Article
- Keywords:
Epstein-Barr virus;
Latent membrane protein 1;
Structure;
Function;
Signal transduction
- From:
Journal of Medical Postgraduates
2003;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Epstein-Barr virus is a kind of herpes virus that has oncogenic potential and is related to the tumorgenesis process of various malignancy. Important advances have been obtained on the study of the structure and functions of Epstein-Barr virus(EBV) latent membrane protein 1(LMP1) and signal transduction pathways mediated by LMP1 in recent years. LMP1 could regulate cellular growth, proliferation, transformation, differentiation, transference and apoptosis by means of signal transduction pathways such as NF-?B, AP-1, JAK/STAT, Ets1, MAPK/ATF2 and cyclin dependent kinase.
