Studies on anticoagulant activity of fucoidan
- VernacularTitle:褐藻多糖硫酸酯抗凝血活性的研究
- Author:
Chunling WANG
- Publication Type:Journal Article
- Keywords:
fucoidan;
anticoagulation;
thrombosis
- From:
Chinese Journal of Marine Drugs
2001;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
The anticoagulant activities of fucoidan extracted from Laminaria japonica were investigated in this study.The results indicated that CT,RT,PT,KPTT,TT could be effectively prolonged after ig administration of fucoidan at the doses of 50,100,200,400mg?kg~(-1) in mice.The plasma Fib level could be significantly lowered after continuous ig administration of fucoidan in mice for 3 weeks;Fucoidan could also remarkably inhibit the thrombosis in vitro after treatment for l week,with obvious loss of the wet and dry weight of thrombi in rats.The results suggested that fucoidan possessed anticoagulant activity and could effectively inhibit the formation of venous thrombus.
