The expressions of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 in the endometrium of women with unexplained infertility
10.3760/cma.j.issn.1673-4130.2009.09.009
- VernacularTitle:MMP-9和TIMP-1在不明原因不孕症患者子宫内膜的表达
- Author:
Hongxian SONG
;
Luming DIAO
- Publication Type:Journal Article
- Keywords:
Infertility;
female;
Matrix metalloproteinase 9;
Tissue inhibitor of metallopro-teinases;
Endometrium
- From:
International Journal of Laboratory Medicine
2009;30(9):852-853,855
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expression situation of matrix metalloproteinase-9(MMP-9) and tissue inhibitor of metalloproteinase-1 (TIMP-1) in the endometrium of women with unexplained infertility and normal endometrium, and to explore the relationship between MMP-9/TIMP-1 expres-sion and unexplained infertility. Methods Immunohistochemieal assay(SP method) was employed to deteet the expression of MMP-9/TIMP-1 in 20 cases of impaired endometrium(unexplained infertility group,endometrial plantation window phase)and 20 cases of normal endometrium(heahhy control group). Results There were different levels of MMP-9/TIMP-1 expression in kytoplasms of glandular epicytes and stromal cells of all endometrial samples. The expression of MMP-9/TIMP-1 was signifi-cantly weaker in unexplained infertility group than that in healthy control group(P＜0.05). Conclusion Low expression of MMP-9/TIMP-1 in the endometrial plantation window phase may be one of impor-tant factors for unexplained infertility.
