Apoptosis of human cervical cancer HeLa cells induced by phosphatidylethanolamine
- VernacularTitle:外源磷脂酰乙醇胺诱导人宫颈癌HeLa细胞凋亡的研究
- Author:
Aiying WANG
;
Xiaoyan HU
;
Zongfang LI
;
Liying LIU
;
Lei NI
;
Lin YU
;
Tusheng SONG
- Publication Type:Journal Article
- Keywords:
phosphatidylethanolamine;
apoptosis;
HeLa cell
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
2009;30(6):738-740,750
- CountryChina
- Language:Chinese
-
Abstract:
Objective Phosphatidylethanolamine (PE) is an important phospholipid component in the cell membrane and is involved in the formation of membrane asymmetry. PE is exposed on the cell surface with phosphatidylserine during apoptosis. However, the effects of PE on cell apoptosis are not clear. In this study, we investigated effects of PE on apoptosis in human cervical cancer HeLa cells. Methods HeLa cells were used as the experiment material, and were divided into five groups: blank PE, respectively. The cell growth was tested by MTT assay; the cell cycle and apoptosis were analyzed using flow cytometry. Results Compared with the control group, PE inhibited the growth of HeLa cells in all the treatment groups in dose- and time-dependent manners, and induced the apoptosis, but did not change the cell cycle. Conclusion PE inhibits the growth of HeLa cells by inducing the apoptosis.
