Studies on the controlled drug delivery system of thermosensitive chitosan-based hydrogel containing doxorubicin in vitro
- VernacularTitle:温敏性壳聚糖凝胶的阿霉素药物体外缓释研究
- Author:
Weiying ZHANG
- Publication Type:Journal Article
- Keywords:
chitosan-based hydrogel;
doxorubicin(ADM);
controlled drug delivery system
- From:
Chinese Journal of Marine Drugs
2001;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the preparation of temperature-sensitive hydrogel system,which is based on chitosan added by ?-glycerophosphate and is used to deliver the doxorubicin,and its delivery property.Methods The doxorubicin-containing temperature-sensitive hydrogel system based on chitosan was prepared;ultraviolet spectrophotometry was used to measure the content of doxorubicin;the drug release by the sustained release system was observed in vitro.Results Doxorubicin-containing temperature-sensitive hydrogel system based on chitosan was prepared and the release curve was obtained to express its delivery property.Conclusion The temperature-sensitive system based on chitosan can be used to deliver doxorubicin.The results provided the experimental basis for improvement of the delivery of doxorubicin.
