HCMV inactivation of blood products by methylene blue photochemical treatment
- VernacularTitle:亚甲蓝光化学法灭活血制品中巨细胞病毒的研究
- Author:
Ping LU
;
Bing LING
;
Yuhua JI
- Publication Type:Journal Article
- Keywords:
Virus inactivation;
Human cytomegalovirus (HCMV)
- From:
Chinese Journal of Blood Transfusion
1988;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effects of methylene blue photochemical(MB-P) inactivation of human cytomegalovirus in blood products.Methods Plasma and red blood cell suspensions containing 10% HCMV and 5?mol/L MB were illuminated by fluorescent light of 38000 Lux for 1 hour, HCMV was used as model viruses for validation of virus inactivation.Results The 50% tissue culture infective dose (TCID_ 50 ) contained in plasma and red blood cell suspensions decreased by 4~6 times.Conclusion MB-P treatment is effective in inactivating the infectivity of HCMV in plasma and red blood cell suspension.
