Relationship between serum PON1-L55M gene polymorphisms and atherosclerotic cerebral infarction
- VernacularTitle:血清对氧磷酶L55M基因多态性与动脉粥样硬化性脑梗死的关系
- Author:
Yunhai LIU
;
Qing HUANG
;
Qidong YANG
- Publication Type:Journal Article
- Keywords:
paraoxonase 1;
gene polymorphism;
cerebral infarction
- From:
Journal of Clinical Neurology
1995;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between paraoxonase1 (PON1) L55M gene polymorphisms and atherosclerotic cerebral infarction(CI)in Hunan Han people. Methods The study population was comprised of 153 atherosclerotic cerebral infarction patients and 153 healthy individuals. The PON1-L55M genotypes were determined by restriction fragment length polymorphism. Results MM genotype was not found both in CI and control group. In CI group, genotypic frequency of LL was 96.7% and LM was 3.3%. The allele frequency of L was 0.984 and M was 0.016. In control group, genotypic frequency of LL was 93.5% and LM was 6.5%. The allele frequency of L was 0.968 and M was 0.032. PON1-L55M polymorphism revealed no significant difference of genotype and allelic distribution in CI patients and controls.Conclusion The polymorphism of PON1-L55M is not related to the incidence of atherosclerotic cerebral infarction in Hunan Han people.
