Effect of different administrations of insulin-like growth factor 1 on cerebral hypoxia-ischemia injury in neonatal rats
- VernacularTitle:不同途径应用胰岛素样生长因子1对新生大鼠缺氧缺血性脑损伤的影响
- Author:
Yuhong LI
;
Zhaofang TIAN
- Publication Type:Journal Article
- Keywords:
cerebral hypoxia;
cerebral ischemia;
insulin-like growth factor 1;
caspase-3
- From:
Journal of Clinical Neurology
1995;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of different administrations of insulin-like growth factor 1(IGF-1) on cerebral hypoxia-ischemia injury in neonatal rats.Methods Forty neonatal rats were divided into four groups: control group, nasal-treated group, intravenous-treated group and sham-operated group. The two treat groups were given IGF-12.5?g (dissolved in 0.1 ml NS) intravenously or by nasal immediately after hypoxia, respectively. Normal saline (0.1 ml) was used intravenously in control group and only disassociation of common carotid artery was performed in sham-operated group. The animals were killed 24 hours after hypoxia. The expression of caspase-3 protein was determined by immunohistochemistry method, also pathological change was studied under light microscope.Results Compared to the control group, the expressions of caspase-3 protein in treat groups were obviously decreased (all (P
