Therapeutic effect observation of selegiline hydrochloride in early stage of Parkinson's disease
- VernacularTitle:盐酸司来吉兰治疗早期帕金森病的疗效观察
- Author:
Peng ZHAO
;
Benshu ZHANG
;
Ying XIAO
- Publication Type:Journal Article
- Keywords:
selegiline;
Parkinson's disease;
efficacy
- From:
Journal of Clinical Neurology
1995;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the efficacy and safety of selegiline in the treatment of patients with Parkinson's disease (PD) at early stage. Methods The randomized and blank controlled study was performed. Sixty PD patients at early stage who had been treated with trihexyphenidyl, amantadine and vitaminE were divided into two groups. One was added to selegiline hydrochloride (5 mg/d) for eight weeks, the other was blank controlled group. Efficacy of selegiline in each patient was evaluated by modified Webster scale. Tolerance and adverse effects were also observed.Results After four and eight weeks, the score of modified Webster scale of selegiline group was lower than that before selegiline treatment (all (P
