Clinical research of Lipo PGE_1 in the treatment of diabetic peripheral neuropathy
- VernacularTitle:脂微球前列腺素E_1治疗糖尿病性周围神经病变的临床研究
- Author:
Xiao WANG
;
Yanyan WANG
;
Ming ZHAO
- Publication Type:Journal Article
- Keywords:
Diabetic mellitus;
Peripheral neuropathy;
Prostaglandin E_1;
Treatment
- From:
Journal of Medical Postgraduates
2003;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To observe the therapeutical effects of Lipo PGE_ 1 in the treatment of diabetic peripheral neuropathy. Methods: 42 cases of type 2 diabetes patients with diabetic peripheral neuropathy were recruited and were divided into two groups at random:therapy group treated with Lipo PGE_ l and control group treated with Vitamine B_ 1 and Vitamine B_ l2 . Results: After a treatment of 20 days,symptoms such as pain,numbness and hypoesthesia in cases of therapy group had been improved at different degrees.Examination of Neuroelectrophysiology indicated an increase of sensory nerves conduction velocity and motor nerve conduction velocity.The effects of therapy group outweighed that of control group. Conclusion: Lipo PGE_ 1 can significantly relief the symptoms of diabetic peripheral neuropathy and increase nerve conduction velocity.The mechanism of action may involve improvement of blood-supply of nerve by vasodilatation and inhibition of platelet aggregation that caused by PGE_ l .
