17?-estradiol inhibit proliferation of thymocytes induced by ConA
- VernacularTitle:17?-雌二醇抑制刀豆蛋白A诱导的胸腺细胞增殖能力
- Author:
Genhong YAO
;
Xuejun SHANG
- Publication Type:Journal Article
- Keywords:
Estrogen;
Thymocyte;
Proliferation;
Cellular immunity
- From:
Journal of Medical Postgraduates
2003;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: The effects of estrogen on cellular immunity were investigated to explore the immunomodulatory properties of estrogen. Methods: In the present study, the in vitro influences of estrogen at 10~(-8),10~(-7 )and 10~(-6) mol/L on the ConA-induced proliferation of thymocytes were determined by MTT assay. Results: The results showed that estrogen at all concentrations we used suppressed the ConA-induced proliferation of thymocytes. The inhibitive effects had dose- and time- dependent pattern. Conclusion: These results suggested that estrogen had inhibiting effects on the cellular immunity.
