Research on the hypoglycemic effection of marine alga Porphyridium cruentum in experimental diabetic mice
- VernacularTitle:紫球藻对四氧嘧啶糖尿病小鼠血糖的调节
- Author:
Liping LIU
;
Jian HUANG
;
Bilian CHEN
;
Juan WANG
;
Min LI
- Publication Type:Journal Article
- Keywords:
Porphyridium cruentum Naegeli;
diabetic mice;
hypoglycemic effect;
antioxidation
- From:
Chinese Journal of Marine Drugs
1994;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the hypoglycemic and antioxidation effects of the red alga Porphyridium cruentum in diabetic mice induced by alloxan. Methods The diabetic models were established by intravenous administration of alloxan 70 mg?kg~(-1).Then the diabetic mice randomly were divided into four groups, Among them ,two groups were given ig the algal biomass 600,1200mg?kg~(-1) ,respectively. After 18 days, the contents of blood glucose, plasma lipids and the activities of SOD were detected. Results Compared with the diabetic model, the algal biomass 600,1200mg?kg~(-1) could significantly decrease the blood glucose.A trend towards lower plasma triglyceride level was observed in test groups. In addition the activity of plasma SOD was significantly enhanced in high dose group. Conclusion Porphyridium cruentum could reduce the level of blood glucose and effectively enhance the ability of antioxidation in the diabetic mice induced by alloxan.
