Effects of indole-2,3-dione on the content and release of monoamine neurotransmitters in rat brain
- VernacularTitle:2,3-吲哚醌对大鼠脑内单胺类神经递质含量与释放的影响
- Author:
Lei WANG
;
Zongrong XU
;
Jing LI
;
Zhantao LIU
;
Wang YUE
- Publication Type:Journal Article
- Keywords:
Indole-2,3-dione;
acetylcholine;
dopamine;
MAO-B
- From:
Chinese Journal of Marine Drugs
1994;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of indole- 2,3-dione on the content and release of monoamine neurotransmitters in rat brain.Methods The Wistar rats were given indole-2,3-dione (50,200mg?kg~(-1),ip), and the content of acetylcholine(Ach) and dopamine(DA) in corpus striatum were detected two hours later;the releases of DA,5-hydroxy-tryptamine(5-HT) and norepinephrine(NE) in cortex and corpus striatum slices were examined before and after perfusion with the artificial cerebrospinal fluid(ACSF)that contained indole-2,3-dione. Results The rats given indole-2,3-dione were observed higher concentration of Ach and DA in their corpus striatum compared with that in cortex. Moreover the results also showed indole- 2,3-dione promoted the release of DA in cortex and corpus striatum slices. Conclusion Indole-2,3-dione can regulate the balance between Ach and DA release in rat brain.
