The Serum Concentration of Prolactin in Schizophrenic Patients with Tardive Dyskinesia
- VernacularTitle:迟发性运动障碍患者血清泌乳素浓度分析
- Author:
Yunlong TAN
;
Dongfeng ZHOU
;
Lianyuan CAO
- Publication Type:Journal Article
- Keywords:
tardive dyskinesia;
schizophrenia;
case-control study;
prolactin
- From:
Chinese Mental Health Journal
2002;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate pathophysiological mechanism of tardive dyskinesia (TD) by comparing the level of serum prolactin ( PRL ) of schizophrenic patients with TD to that of patients without TD (TD-) and normal volunteers. Methods: To assay the level of serum PRL in normal controls (n=44), chronic schizophrenic patients with TD (n=46), and without TD (n=46) by radio-immunity assay (RIA). The TD group and TD^group were matched by age, medication,disease duration matched. AIMS (abnormal involuntary movement scale) was used to measure the severity of TD. Results: The concentration of PRL in serum in the normal group (617?358?IU/ml), patients with TD (1277?1011?IU/ml) and TD- (913?602?IU/ml) had significant difference (P0.05). Conclusion: The concentration of PRL in serum in patients with TD was increased significantly.
