Mutational analysis of FUT1 and FUT2 genes in para-Bombay individuals
- VernacularTitle:类孟买型的FUT1和FUT2等位基因突变的分析
- Author:
Yuqing SU
;
Guoguang WU
;
Tianli WEI
;
Quong YU
;
Yanlian LIANG
;
Wenhua HUANG
- Publication Type:Journal Article
- Keywords:
Para-Bombay;
FUT1 gene;
FUT2 gene;
Frame-shift mutation
- From:
Chinese Journal of Blood Transfusion
1988;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the mutation of FUT1 and FUT2 genes in para-Bombay individual.Methods Direct DNA sequencing of FUT1 and FUT2 gene coding region were analyzed in two individuals with para-Bombay phenotype.Results One individual lost one of the three AG repeats located at nucleotides 547~552 of the FUT1 gene, whereas two of the three T repeats located at nucleotides 880~882 were deleted in the other.Conclusion Two frame-shift mutations of FUT1 gene are responsible for the H antigen deficiency
