Growth Inhibition of Tumor by Recombinant SEA
- VernacularTitle:重组金葡菌肠毒素A的抗癌效应研究
- Author:
Quanbin XU
;
Vanhong ZHANG
;
Leilei ZHANG
;
Chuanxuan LIU
;
Qingjun MA
- Publication Type:Journal Article
- Keywords:
staphylococcal enterotoxin A;
tumor;
immunotherapy
- From:
Chinese Journal of Cancer Biotherapy
1995;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the antitumor activity of recombinant SEA for therapy of B16 melanoma established in C57BL/6 mice. Methods:C57BL/6 mice with melanoma were treated with the purified rSEA. The tumors were isolated and weighted. Results:Tumor growth was apparently inhibited by rSEA at high, middle, and low doses intraperitone-ally, whose inhibition ratio were 79.3% , 75.6 % and 73. 8% respectively. rSEA treatment in situ could inhibit tumor growth more effectively(90.6% ). Further study showed that numerous CD8+ and CD4+ T cell were infiltrated in tumor tissues, which were consistent with tumor growth inhibition induced by rSEA. Conclusions: rSEA could inhibit tumor growth effectively, especially the treatment in situ. This study paves the way for tumor immunotherapy with targeted SEA.
