Effect of simvastatin on proliferation and migration of cultured porcine coronary smooth muscle cells induced by oxidized low density lipoprotein
- VernacularTitle:辛伐他汀对氧化型低密度脂蛋白诱导的猪冠状动脉平滑肌细胞增殖和迁移的影响
- Author:
Changyong ZHOU
;
Zhihong CHE
;
Huali GU
- Publication Type:Journal Article
- Keywords:
Simvastatin;
Lipoproteins, LDL;
VSMC;
Cells, cultured
- From:
Chinese Journal of Interventional Cardiology
1993;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the inhibition effects of simvastatin on proliferation and migration of cultured porcine coronary vascular smooth muscle cells (SMCs) induced by oxidized lower density lipoprotein (OX-LDL). Methods Porcine coronary SMCs were incubated with serum-free medium containing different concentrations of simvastatin. Infiltration of ~3H-TdR into SMC DNA was measured as an index of cell proliferation. Simvastatin's effect on migration was tested with Sarkar's technique. Results Different concentrations of simvastatin (10~(-8)-10~(-5) mol/L) caused a decrease in ~3H-TdR infiltration in porcine coronary SMC. The migration number of porcine coronary SMCs also decreased proportional to the simvastatin concentration. Conclusion Simvastatin can inhibit the proliferation and migration of porcine coronary SMCs stimulated by OX-LDL in a dose-dependent manner.
