The Relationship of Infection and Inflammation with Coronary Restenosis after Percutaneous Coronary Interventions.
10.4070/kcj.2001.31.10.988
- Author:
Shin Bae JOO
1
;
Myung Ho JEONG
;
Woo Kon JEONG
;
Ok Young PARK
;
Sang Rok LEE
;
Won KIM
;
Kye Hun KIM
;
Kun Hyung KIM
;
Joo Hyup YUM
;
Jae Young RHEW
;
Nam Ho KIM
;
Young Keun AHN
;
Jong Hee SHIN
;
Jeong Gwan CHO
;
Jong Chun PARK
;
Jung Chaee KANG
Author Information
1. The Heart Center, Chonnam National University Hospital, The Research Institute of Medical Sciences, Kwang Ju, Korea.
- Publication Type:Original Article
- Keywords:
Percutaneous coronary intervention;
Inflammation
- MeSH:
Acute Coronary Syndrome;
Angiography;
Blood Sedimentation;
Chlamydophila pneumoniae;
Coronary Restenosis*;
Diagnosis;
Follow-Up Studies;
Helicobacter;
Humans;
Inflammation*;
Percutaneous Coronary Intervention*
- From:Korean Circulation Journal
2001;31(10):988-995
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND AND OBJECTIVES: Possible correlations between the serologic status concerning Cytomegalovirus(CMV), Chlamydia pneumoniae (CP), Helicobacter pylori(HP), their related markers of C-reactive protein(CRP), erythrocyte sedimentation rate(ESR), and the restenosis(RS) in patients underwent percutaneous coronary intervention(PCI) were analyzed. Materials and METHODS: The 142 patients(58.010.9 year-old, M;F=116:26) with 189 coronary lesions, who underwent follow-up angiography after PCI, were evaluated. RESULTS: The overall RS rate was 47.1%(89/189), and the RS rate according to clinical diagnosis was 50.6% in acute myocardial infarction(MI), 41.8% in unstable angina(UA), 6.3% in stable angina(SA), and 1.3% in old MI. The values of RS rate in acute MI and UA were higher than those of old MI and SA(p=0.02). Thrombolysis In Myocardial Infarction(TIMI) flow was significantly lower in group with RS than without RS(p=0.039). Seropositivities of CMV, CP, HP were not different between groups with and without RS. Titers of CMV and HP were not different between two groups. Positivity of CRP was 56.3% in group with RS and 30.2% in group without RS(p=0.005). Titers of ESR and CRP were higher in group with RS than without RS(20.322.4 mm/hr, 2.24.5 mg/dL vs. 11.811.6 mm/hr, 0.70.8 mg/dL, p=0.007, p=0.010 respectively). CONCLUSION: RS rate after PCI is higher in patients with acute coronary syndrome and low TIMI flow. Inflammatory markers, such as CRP and ESR, might be associated with the RS after PCI.
