Apoptosis and expression of Fas,TNF-? and Bcl-2 in HAM/TSP and its significance
- VernacularTitle:细胞凋亡及其相关因子在HAM/TSP中的表达及其意义
- Author:
Yingxiu XIAO
;
Xuan ZHENG
;
Weiduan ZHUANG
- Publication Type:Journal Article
- Keywords:
HAM/TSP;
apoptotic correlation factors
- From:
Journal of Clinical Neurology
1993;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the apoptosis of peripheral blood lymphocyte cells in patients with HAM/TSP and the roles of Fas, TNF-? and Bcl-2 in occurrence and progression of HAM/TSP.Methods The single cell gel electrophoresis (comet assay) was used to detect the apoptosis of lymphocyte cells in 8 patients with HAM/TSP, 8 cases with other inflammatory neurologic diseases (OIND) and 8 healthy blood donors. The Fas, TNF-? and Bcl-2 protein expressions were quantitatively determined by flow cytometry from 8 cases of HAM/TSP.Results The apoptotic ratio of lymphocyte cells in patients with HAM/TSP significantly increased compared with the controls (P
