Neuroprotective effects of Mannitol combined with Nimotop in treatment of ischemic reperfusion injury in rats
- VernacularTitle:甘露醇与尼莫通联合应用对大鼠脑缺血再灌注损伤保护机制的研究
- Author:
Zhenwei ZHAO
;
Youzhi QU
;
Guodong GAO
- Publication Type:Journal Article
- Keywords:
cerebral ischemia reperfusion;
Mannitol;
Nimotop;
NO;
apoptosis
- From:
Journal of Clinical Neurology
1993;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study neuroprotective machanisms of Mannitol combined with Nimodipine in treatment of ischemic reperfusion injury in rats. Methods Seventy-two SD rats were randomly divided into six groups (Group A:sham-operated group;Group B:model group;Group C:low-dose Mannitol group;Group D:high-dose Mannitol group;Group E:Nimotop group;Group F:Mannitol combined with Nimotop group). Both nitrate reductase and TUNEL methods were respectively used to measure NO content and apoptotic neurons in the brains.Results NO content and apoptotic neurons were higher in group B than those in group A (P0.05). NO content and apoptotic neurons were lower in group F than in group C,D and E (all P
