Effect of Exelon on cognitive function of chronic cerebral hypoperfusion rats
- VernacularTitle:艾斯能对慢性低灌注大鼠认知功能的影响
- Author:
Lu SUN
;
Jing HUANG
;
Yuanwu MEI
- Publication Type:Journal Article
- Keywords:
cerebral hypoperfusion;
cognitive function;
ERP;
cholinesterase;
Exelon
- From:
Journal of Clinical Neurology
1993;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of Exelon on cognitive function of chronic cerebral hypoperfusion rats and its cholinergic mechanism.Methods 112 rats were randomly separated into four groups (normal, hypoperfusion, normal saline and Exelon). Bilateral common carotid arteries were ligated for models of cerebral hypoperfusion in the rats except normal group. 4 weeks later, Exelon and normal saline were used to treat the rats in Exelon group and normal saline group respectively for 6 weeks. Then the values of AchE lever and Ach fiber density together with the results of experiments in water maze and the values of event-related potential (ERP) were recorded and compared with each group.Results Comparing with the normal group, the water maze completion time of the hypoperfusion group was significantly delayed, error frequency significantly increased, the latency of ERP much extended, the AchE level and Ach fiber density evidently decreased(all P
