Comparison of serum Cystatin C and creatinine in the detection of glomeruli filtration function in diabetic patients
- VernacularTitle:血清半胱氨酸蛋白酶抑制剂C与肌酐在评价糖尿病患者肾小球滤过功能中的比较研究
- Author:
Haixia LI
;
Honghua WU
;
Guobin XU
;
Xiaohui GUO
;
Tiean XIA
- Publication Type:Journal Article
- Keywords:
Cysteine proteinase inhibitors;
Glomerular filtration rate;
Diabetes mellitus
- From:
Chinese Journal of Laboratory Medicine
2000;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective This study was designed to estimate the value of Cystatin C, compared to routine marker (Scr、Ccr), as the screening marker for reduced GFR in type 2 diabetes patient. Methods The study was performed on 51 type 2 diabetic patients, and GFR was estimated by the plasma clearance of ~ 99m Tc-DTPA. Sensitivity and specificity for the diagnosis of renal impairment were calculated by receiver operating characteristic (ROC) curves for above three parameters.Results Correlation coefficients with ~ 99m Tc-DTPA were-0.744 for serum Cystatin C,-0.658 for serum creatinine, 0.625 for creatinine clearance (all P
