The diagnostic value of secretory phospholipase A_2 and lysophosphatic acid for ovarian cancer
- VernacularTitle:磷脂酶A_2和溶血磷脂酸在卵巢癌诊断中的价值
- Author:
Manle DUAN
;
Fan WU
- Publication Type:Journal Article
- Keywords:
Phospholipases A;
Lysophospholipids;
Ovarian cancer
- From:
Chinese Journal of Laboratory Medicine
2000;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the diagnostic value of secretory phospholipase A2 (sPLA2) and lysophosphatic acid (LPA) for ovarian cancer and evaluate the correlation of sPLA2 activity and LPA level to the prognosis in the patients with ovarian cancer.Methods ~3H oleic acid labeled E. coli membrane and spectrophotometry were used to detect the original and recurrent ovarian cancer. The motive observation between sPLA2 activity and LPA level was done.At the same time, The sensitivity and specificity for the diagnosis of ovarian cancer were analyzed.Results Comparing the original ovarian cancer group with the ovarian benign tumor group, the difference between sPLA2 activity (24.47 ?5.64 U/L,4.94 ?1.86 U/L) and LPA levelc(6.35 ?2.32 ?mol/L,1.92 ?0.75 ?mol/L) were significantly (P
