Role of imprinted gene Insulin-like growth factor 2 in fetal growth
- VernacularTitle:印迹基因胰岛素样生长因子-2在胎儿生长发育中的作用
- Author:
Yimin DAI
;
Yali HU
- Publication Type:Journal Article
- Keywords:
Imprinted gene;
Insulin-like growth factor 2;
Placenta;
Fetal
- From:
Journal of Medical Postgraduates
2003;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Genomic imprinting plays a fundamental role in mammal fetal growth and behavior. Abnormal expression of imprinted genes is associated with some genetic diseases and cancers. Imprinted insulin-like growth factor 2 (IGF-2) controls fetal growth by regulating nutrient transportation in placenta. Paternal uniparental disomy, duplication of paternal allele and loss of imprinting are 3 molecular mechanisms of IGF-2 overexpression that can cause Beckwith-Weidemann’s syndrome (BWS). Some assisted reproductive techniques may cause some epigenetic changes that affect embryonic and postnatal development.
