Enhancement of fracture healing with bone graft substitutes
- VernacularTitle:骨移植替代材料在加速骨折治疗中的应用
- Author:
Junying SUN
- Publication Type:Journal Article
- Keywords:
Growth factors;
Bioceramics;
Composite grafts;
Bone healing;
Trea tment
- From:
Chinese Journal of Orthopaedic Trauma
2004;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
High-energy fractures are known to result in a long healing proce ss and a high incidence of nonunion. In the traditional treatment of high-energ y fractures, bone grafting or bone substitute grafting is applied only after the delayed union or nonunion has already been confirmed. Secondary interventions t o treat nonunion are associated with a high morbidity of complications and a lon g time recovery. Charnley (1961) first recommended prophylactic bone grafting in treatment of high-energy fractures to reduce total time of fracture healing. H owever, autogenous bone graft has certain drawbacks, such as limited harvest ava ilable and serious complications at the donor site. In order to overcome these p roblems, various bone graft substitutes, such as growth factors, bioceramics and composite grafts, have been developed as early grafting materials.
