Studies on the absorption and distribution of low molecular N-trimethyl chitosan chloride in mice
- VernacularTitle:低分子甲壳铵在小鼠体内吸收与分布的研究
- Author:
Qifeng LIU
;
Huixia REN
;
Jianguo ZHANG
- Publication Type:Journal Article
- Keywords:
low molecular N-trimethyl chitosan chloride;
body absorption;
body distribution
- From:
Chinese Journal of Marine Drugs
1994;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the absorption and distribution of low molecular N-trimethyl chitosan chloride in mice.Methods Using tritium marking method to determine the concentrations of low molecular N-trimethyl chitosan chloride in serum after oral administration.Its pharmacokinetics were analysed by DAS ver1.0 program and the distributions in tissues were examined. Results The pharmacokinetics of low molecular N-trimethyl chitosan chloride were consistent with two-compartment model.The radioactive concentrations in liver,kidney,lung and spleen were higher than those in other tissues.And the radioactive concentration in cancer was higher. Conclusion Low molecular N-trimethyl chitosan chloride could be absorbed after oral administration.It was easily conjugate with cancer surface and could be developed as an anticancer drug for oral use in the future.
