Effect of different altitudes on the morphology of pituitary ACTH cells in rats
- VernacularTitle:不同海拔对大鼠腺垂体促肾上腺皮质激素细胞影响的形态学研究
- Author:
Juxiang HE
;
Paili GEN
;
Yuzhang TIAN
;
Hongfu WU
;
Haihong ZHU
;
Min ZHAO
- Publication Type:Journal Article
- Keywords:
High altitude;
ACTH cells;
Immunohistochemisty;
Ultrastruacture
- From:
Journal of Medical Postgraduates
2003;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To observe the morphologic changes of pituitary adrenocorticotrophic hormone (ACTH) cells in Wistar rats at different altitudes, and clarify the mechanism of stress reaction to hypoxia in ACTH cells. Methods: Wistar rats were divided into three groups and moved to different altitudes (1700 m, 3100 m, 4050 m). After 12 days, changes of ACTH cells were observed by using immunohistochemisty, image analysis and electron microscopy. Results:The ratio (R) of immunoreactive cell area to scanned area and mean optical density (A) increased at higher altitude with statistically different R values between groups of 1700 m and 4050 m (P
