The expression of HER2 and P-gp and its prognostic significance in osteosarcoma
- VernacularTitle:骨肉瘤组织中HER2、P-糖蛋白的表达与预后的关系
- Author:
Zhiwei CHEN
;
Sujia WU
- Publication Type:Journal Article
- Keywords:
P-gp;
HER2;
Osteosarcoma;
Multidrug resistance
- From:
Journal of Medical Postgraduates
2003;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
HER2 and P-gp are expressed in most of the human osteosarcoma tissue. The multidrug resistance of osteosarcoma is mediated by P-gp. The insusceptibility of human osteosarcoma to chemotherapy and the poor prognosis is correlated with the expression of P-gp. The expression of the carcinogene HER2 is a prognostic risk factor of the malignancy and metastasis of osteosarcoma. The review will narrate the expression of the HER2 and P-gp in osteosarcoma and its prognostic significance.
