Changes and correlation analysis between serum homocysteine and plasma fibrinogen in ischemic cerebrovascular disease
- VernacularTitle:缺血性脑血管病血清同型半胱氨酸和纤维蛋白原水平的变化及其相关性分析
- Author:
Hua LI
;
Chuanqiang PU
;
Zongjian YIN
- Publication Type:Journal Article
- Keywords:
cerebral infarction;
homocysteine;
folate;
fibrinogen
- From:
Journal of Clinical Neurology
1988;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the change of serum homocysteine (Hcy) and plasma fibrinogen (Fg) levels in patients with ischemic cerebrovascular diseases (ICVD) and the correlation between Hcy and Fg.Methods Blood samples were collected from 74 patients with ICVD and 40 controls. The concentrations of Hcy, folate and Fg were determinated by means of fluorescence polarization immunoassay, electrochemiluminescence, and immunoturbidimetry, respectively. In the meantime, plasma lipid was detected by routine method.Results Both Hcy and Fg levels in the patients with ICVD increased significantly as compared with the controls (all P0.05). Multivariate logistic regression analysis indicated that hypertension, high cholesterol, high Fg and high Hcy concentrations played significiant roles in ICVD.Conclusion Both hyperhomocysteinemia and hyperfibrinogenemia are independent risk factors of ICVD.
