Changes of serum nitric oxide and nitric oxide synthase in acute cerebral hemorrhage with multiple organ dysfunction syndrome caused by systemic inflammatory response syndrome
- VernacularTitle:急性脑出血并发全身炎症反应综合征致多器官功能障碍综合征患者血清一氧化氮、一氧化氮合酶的变化
- Author:
Li LI
;
Hongzhi GUO
- Publication Type:Journal Article
- Keywords:
cerebral hemorrhage;
multiple organ dysfunction syndrome;
systemic inflammatory response syndrome;
nitric oxide;
nitric oxide synthase
- From:
Journal of Clinical Neurology
1988;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the possible mechanism of acute cerebral hemorrhage with systemic inflammatory response syndrome (SIRS) which caused multiple organ dysfunction syndrome (MODS), and to investigate the significance of serum nitric oxide (NO) and nitric oxide synthase (NOS) in the development of acute cerebral hemorrhage from SIRS to MODS.Methods The incidence rate of acute cerebral hemorrhage leading to SIRS and MODS was investigated. Serum NO and NOS levels in 73 patients with acute cerebral hemorrhage were detected dynamically by nitratase and chromometry methods. 20 normal healthy people were adopted as control group.Results The incidence rate of cerebral hemorrhage accompanied with SIRS was 47.95%(35/73),74.29%(26/35) of which leaded to MODS. 73 patients serum NO and NOS levels were elevated obviously, and the differences were significant compared with control group (all P
