Effect of histamine in paraventricular nucleus on the development of neurogenic pulmonary edema
- VernacularTitle:室旁核内组胺在神经源性肺水肿发病中的作用
- Author:
Lijuan SHI
;
Rong DONG
;
Xiaohong ZHANG
- Publication Type:Journal Article
- Keywords:
neurogenic pulmonary edema;
paraventricular nucleus;
histamine
- From:
Journal of Clinical Neurology
1988;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect of histamine in paraventricular nucleus (PVN) on the development of neurogenic pulmonary edema (NPE).Methods NPE models of rabbits were made and H 1 receptor antagonist (chlorpheniramine, H 1 group), H 2 receptor antagonist (Cimetidine, H 2 group) or normal sodium (NS group) were injected into PVN of rabbits utilizing the technique of stereotaxis. The degree of pulmonary edema was observed, the content of histamine in PVN was measured by high performance liquid chromatogram, and the ration of lung-water and A/P value were calculated.Results (1) Compared with control group and sham operation group, the content of histamine of PVN in NPE group obviously increased ( P
