Content changes of nitric oxide in rat model of pancreatitis
- VernacularTitle:急性胰腺炎胰腺组织一氧化氮含量变化及意义
- Author:
Zhenpeng LIU
;
Longdian CHEN
- Publication Type:Journal Article
- Keywords:
Acute pancreatitis;
Nitric oxide;
Rats
- From:
Journal of Medical Postgraduates
2003;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To identify the role of NO changes in L-arginine induced model of acute pancreatitis in rats. Methods: Acute pancreatitis was induced with a single intraperitoneal injection of 500 mg/100 g body weight of L-arginine. The contents of NO were measured at 6 h,12 h,24 h,48 h,72 h after injection. Results: The content changes of NO in the pancreatic tissues of the rats were decreasing with pancreatitis exacerbating and reaching the lowest value in 48 h when the severity of pancreatic necrosis became serious, then began to rise slowly. The controls had not changed markly. Conclusion: The contents of NO decreasing is relative to the severity of pancreatic necrosis.
