Study on application of spreading cellules to investigate on skin absorption possibility of drug from TTS - nitroglycerin
- Author:
Hoang Minh Chau
- Publication Type:Journal Article
- Keywords:
skin, drug, cell
- MeSH:
Nitroglycerin;
Pharmaceutical Preparations;
Skin
- From:Pharmaceutical Journal
2005;0(5):23-25
- CountryViet Nam
- Language:Vietnamese
-
Abstract:
The researchers built targets and way to handle skin and built quantitative method notroglucerin by high-performance liquid chromatography (HPLC) and quantitative method total nitroglucerin content in sticking-plaster Discotrin 36mg with area of 13,3cm2. The study was carried out in 6 samples and average with RSD = 0,47%, from there find out exactly nitroglycerin level on 1cm2 to evaluate permeation of nitroglycerin through skin in different temperatures ( 41oC, 37oC, 25oC). The result showed that the higher temperature, the more Nitroglycerin is permeated. The permeation of nitroglycerin through skin is defferent in each animal
