Studies on the Association of Human Leukocyte Antigen ClassⅡAlleles with Advanced Hepatosplenic Schistosomiasis japonica
- VernacularTitle:Ⅱ类人白细胞抗原等位基因与晚期肝脾型日本血吸虫病的相关性研究
- Author:
Junhua ZHANG
;
Wenqi LIU
;
Yonglong LI
;
Xiaochun LONG
- Publication Type:Journal Article
- Keywords:
Hepatosplenic schistosomiasis;
HLA-Ⅱ antigens;
Alleles
- From:
Chinese Journal of Parasitology and Parasitic Diseases
1987;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the association of human leukocyte antigen classⅡ(HLA-Ⅱ) alleles with genetic susceptibility and resistance to advanced hepatosplenic schistosomiasis japonica. Methods The allelic types of HLA-DRB1, DPA1, DQA1 and DQB1 were detected by polymerase chain reaction with sequence-specific primers (PCR-SSP) technique in 46 patients with advanced hepatosplenic schistosomiasis, characterized with extensive liver fibrosis. Another 43 subjects with chronic schistosomiasis were used as control. The statistical significance of differences in allelic frequencies was determined by ? 2 test. Results The frequencies of HLA-DRB1*04, DPA1*0103, DQA1*0601, DQB1*0201 in advanced patients were markedly higher than those in control group, while the frequencies of HLA-DQA1*0501 and DQB1*0601 in control group were higher than those in advanced patients. Conclusion The study indicated that HLA-DRB1*04, DPA1*0103, DQA1*0601 and DQB1*0201 showing a positive, statistically significant (P
