Clinical study on effect of common methylenetetrahydrofolate reductase gene mutation on coronary artery disease in hypertension
- VernacularTitle:亚甲基四氢叶酸还原酶基因多态性对高血压患者冠心病发病的影响
- Author:
Jie NIU
;
Zhe ZHANG
;
Mingzhe CHEN
- Publication Type:Journal Article
- Keywords:
MTHFR;
Homocysteine;
Coronary artery disease;
Hypertension
- From:
Chinese Journal of Interventional Cardiology
1996;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association between the MTHFR gene C677T mutation and CAD in patients with hypertension. Methods Of the 103 cases of patients with hypertension who underwent coronary angiography, 58 were CAD and 45 were not. MTHFR genotypes were identified by PCR and restriction fragment length polymorphism analysis with Hinf I digestion. Plasma folate was determined by radioimmunoassay. Plasma HCY was determined by HPLC. Results The frequencies of T677 allele (0.45) in the CAD group were markedly higher than those in the control group (0.33, P=0.03), plasma homocysteine level in the CAD group (17.73?2.22 ?mol/L) was also significantly higher than that in the control group (12.18?1.23 ?mol/L, P=0.037). There was no significant difference in the concentrations of folate for the two studied groups. Conclusion The MTHFR gene T677 variant is the genetic high risk factor for CAD in patients with hypertension. It can induce the hyperhomocysteinemia, potentially contributing to the pathogeny of CAD.
