Association between CD40 ligands pregnancy-associated plasma protein-A and angiographic morphology of coronary lesions in patients with coronary heart disease
- VernacularTitle:冠状动脉斑块形态与CD40配体及妊娠相关蛋白酶-A的关系
- Author:
Xuping LI
;
Zhihui ZHANG
;
Shenghua ZHOU
- Publication Type:Journal Article
- Keywords:
Coronary angiography;
Coronary disease;
Antigens, CD40;
Ligands;
Pregnancy-associated plasma protein-A
- From:
Chinese Journal of Interventional Cardiology
1996;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective The aim of this study was to examine plasma levels of CD40 ligands (CD40L) and pregnancy-associated plasma protein-A in patients with angiography type Ⅱ lesions (representing plaque rupture with or without thrombosis), and to evaluate the role of PAPP-A in the development of plaque disruption. Methods The morphology of the plaques in 68 patients was studied and analyed by means of coronary angiography. According to the morphology of the plaques, the patients were divided into type Ⅰ group (smooth borders, n=19), type Ⅱ group (irregular lesions, n=33), and type Ⅲ group (long lesions, n=16). The plasma level of CD40L, PAPP-A, creatine kinase (CK), and MB isoenzyme of CK (CK-MB) was measured in all the patients. Results Mean plasma CD40L [(3.21?2.08)mg/L] in type Ⅱ group was significantly higher than that in the type Ⅰ group [(1.03?0.98)mg/L, P
