Expression and related function of erythropoietin and its receptor in ovarian epithelial tumor
- VernacularTitle:促红细胞生成素及其受体在卵巢癌细胞的表达及相关作用的实验研究
- Author:
Muya MA
;
Zemin YANG
;
Mei FENG
- Publication Type:Journal Article
- Keywords:
Ovarian neoplasms;
Erythropoietin;
Erythropoietin receptor;
,Anaemia
- From:
Cancer Research and Clinic
2008;20(6):380-381,394
- CountryChina
- Language:Chinese
-
Abstract:
Objective To detect the expression of EPOR in ovarian epithelial tumor. Study the biologic effect of rHuEPO to ovarian epithelial tumor cell H08910. Methods RT-PCR analyses were used to detect the expression of EPOR in ovarian epithelial tumor cell, FCM assay was used to detect rHuEPOs effect to ovarian epithelial tumor cell proliferation and inhibition ratio. Results There is EPOR expressions in ovarian epithelial tumor cell. rHuEPO could reduce ovarian epithelial tumor cell expressions (P <0.01). Conclusion The lower expression of EPOR was observed in ovarian epithelial tumor cell. Use rHuEPO couldn't promote the cancer's progression and bring negative effect in clinical practice. Further clinical research is required to prove it.
