Study on V?24-V?11NK T cells in peripheral blood of patient with systemic lupus erythematous
- VernacularTitle:系统性红斑狼疮患者外周血V?24-V?11自然杀伤T细胞致病性的研究
- Author:
Li MA
;
Lan CHU
;
Jie YANG
;
Hong LI
- Publication Type:Journal Article
- Keywords:
Systemic lupus erythematous;
Flow cytometry;
Cytokines
- From:
Chinese Journal of Laboratory Medicine
2001;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the changes of amount and function of V?24-V?11 natural killer (NKT) cells in peripheral blood of patients with systemic lupus erythematous (SLE). Methods The amount of V?24-V?11NK T cells and expression rate of cluster of differentiation (CD) 69, interleukin4 IL-4 and interferonr (IFN)-?on these cells in 32 cases of SLE and 30 healthy persons were tested by flow cytometry.Results The amount of V?24-V?11NK T cells in SLE group was 0.44%?0.25% and that in control group was 1.07%?0.23%. The expression rate of CD69 in SLE group was 5.26%?2.12% and that in control group was 11.47%?2.86% before cell activation. It was 56.61%?0.47% and 96.71%?~0.33% respectively after cell activation. INF-?on NK T cells in SLE group was 19.32%?6.45 pg/ml and lower than that in controls (33.65?11.91 pg/ml,P
