Two Lung Masses with Different Responses to Pemetrexed.
10.3904/kjim.2010.25.2.213
- Author:
Kwang Young PARK
1
;
Jae Wook JUNG
;
Seung Bum NAM
;
Ho Jin LEE
;
Hyo Seok KIM
;
Yoon Hee CHOI
;
Jae Cheol LEE
Author Information
1. Department of Internal Medicine, Korea Cancer Center Hospital, Seoul, Korea. jclee@kcch.re.kr
- Publication Type:Case Report
- Keywords:
Lung neoplasms;
Pemetrexed;
Neoplasms, multiple primary;
Drug resistance
- MeSH:
Aged;
Antimetabolites, Antineoplastic/*therapeutic use;
Antineoplastic Agents/therapeutic use;
Carboplatin/therapeutic use;
Carcinoma, Squamous Cell/*drug therapy/pathology;
Deoxycytidine/analogs & derivatives/therapeutic use;
Drug Resistance, Neoplasm;
Female;
Glutamates/*therapeutic use;
Guanine/*analogs & derivatives/therapeutic use;
Humans;
Lung Neoplasms/*drug therapy/pathology;
Neoplasms, Second Primary/*drug therapy/pathology
- From:The Korean Journal of Internal Medicine
2010;25(2):213-216
- CountryRepublic of Korea
- Language:English
-
Abstract:
We described here a patient who had two lung masses. Although the two masses had the same histology and a similar good response to initial chemotherapy with gemcitabine and carboplatin, the response to pemetrexed as a second-line treatment was different after re-growth of the tumors. These two lung masses could have originated from different clones or they could have progressed through different paths of molecular pathogenesis after metastasis, which would lead to different tumor characteristics, including their chemosensitivity. Regardless of their pathogenetic mechanisms, it seems important to recognize that tumors with the same histology that develop in one patient can have different responses to drugs.
