Evaluation of serum CA125 in literatures of ovarian neoplasms based on evidence-based medicine
- VernacularTitle:血清CA125在卵巢癌诊断中的价值及文献评价
- Author:
Shan LI
;
Xue QIN
;
Weihua HE
- Publication Type:Journal Article
- Keywords:
CA125 antigen;
Ovarian neoplasms;
Evidence-based medicine
- From:
Chinese Journal of Laboratory Medicine
2001;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess the serum CA125 in literatures of ovarian neoplasms based on evidence-based medicine.Methods The relating reports published in the years of 1996—2003 were collected and evaluated according to the evidence-based medicine principles. Main outcomes include design methods,sample screening,establishment of control group,blind method,criteria of diagnostic trials.Results In the reports collected, gold standard was adopted in 62 reports and independent blind method was adopted in 23 reports, criteria of diagnostic trials such as sensitivity, specificity and likelihood ratio were incomplete and there was no descriptions okf potential bias controlling. As for the literatures sharing the same method ,their conclusion did not totally accord with each other.Conclusion There is no evidence to implicate that serum CA125 was considered an independent predictor of the diagnosis of ovarian cancer.
