Dynamic contrast-enhanced MRI of breast disease: correlation of MR findings with vascular endothelial growth factor and microvessel density
- VernacularTitle:乳腺良恶性病变动态增强MRI与血管内皮生长因子及微血管密度相关性的研究
- Author:
Sujian LI
;
Changyu ZHOU
;
Zeping YU
;
Xiaogan ZHENG
- Publication Type:Journal Article
- Keywords:
Breast disease;
Dynamic contrast-enhanced;
Magnetic resonance imaging;
Microvessel density;
Vascular endothelial growth factor
- From:
Journal of Medical Postgraduates
2004;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To determine the relation dynamic contrast-enhanced magnetic resonance imaging (MRI) and histologic features and angiogenesis of breast disease. Methods: Forty patients with breast disease, diagnosed by histopathology were reviewed, including imaging and pathological data. Dynamic MRI was performed by a fat-suppressed 3D-FSPGR sequence ,Time-Signal curve was acquired by Functool 2 software, then early-phase enhancement rate and E max , T max were acquired. The mean MVD and VEGF expression of the lesions were measured with immunohistology. Evaluation of inflammatory changes was assessed by histology. Results: The MVD , VEGF expression and inflammatory scores of malignant tumor were significantly higher than that of benign tumor(P0.05), The Time-SI curve between malignant and benign was significant different(P
