Advance on insulin-like growth factor binding protein in human malignant tumors
- VernacularTitle:胰岛素样生长因子结合蛋白在人类恶性肿瘤中的研究进展
- Author:
Wenbin HUANG
;
Xiaojun ZHOU
- Publication Type:Journal Article
- Keywords:
Insulin-like growth factor;
Insulin-like growth factor protein;
Tumor
- From:
Journal of Medical Postgraduates
2004;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Insulin-like growth factors, their receptors and insulin-like growth factor binding protein constitutes insulin-like growth factor system. Studies in vivo and vitro suggest that they can regulate cell growth and proliferation. Insulin-like growth factors have a potent mitogenic effects which dependent on interaction between insulin-like growth factors and their receptors. IGFBP family contains six high-affinity members with variable functions and mechanisms of actions. In addition to functioning as simple carrier proteins, IGFBP can inhibit or promote IGFs by IGF-dependent or IGF-independent mechanism. Recent findings show that the IGFBP is correlated with the initiation and progression of tumor growth.
