Role of airway inflammation in the pathogenesis in patient with aspirin-induced asthma
- VernacularTitle:阿司匹林性哮喘的呼吸道炎症在其发病机制中的作用
- Author:
Xiaofeng XIN
;
Yi SHI
- Publication Type:Journal Article
- Keywords:
Asthma;
Aspirin;
5-Lipoxygenase;
LTC 4 synthase
- From:
Journal of Medical Postgraduates
2004;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
The numbers of eosinophils and mast cells expressing 5-lipoxygenase of airway in aspirin-induced asthma (AIA) increased. LTC 4 synthase, the terminal enzyme for cys-LT production, is overexpressed markedly in bronchial biopsy specimens of most patients with AIA. These characterized the unique airway inflammation of AIA which may illuminat the pathogenesis of AIA to some extent.
